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Sunday sees the inaugural Wear-Tyne derby since 2024, but will it be – Sunderland or Newcastle?
"For most of last season, you couldn't have imagined the Wearside club getting promoted and holding their own with Eddie Howe's Newcastle, never mind being above them in the table," remarked pundit Chris Sutton.
"The situation is very different now, and the way Sunderland play leads me to believe they've got a solid shot."
The analyst is providing forecasts for all 380 Premier League games this season, against artificial intelligence, the public and a assortment of guests.
For week 16, he is challenged by England Gaming star Daniel 'Stingray' Ray.
Ray is competing for honours for the national gaming squad – the Football Association's recognised esports team – at the EA Sports FC European esports championship finals tournament, which takes place at Twickenham Stadium on Saturday.
You can watch Uefa's video platform, Instagram Live and short-form video channels, as well as the official Twitch channel and YouTube and the national team's Twitch.
What are your thoughts with their predictions? Share your own guesses below.
The fan-favourite scoreline chosen for each game is featured in the leaderboards at the end of this page.
Predicting the right outcome (selecting a win, draw or defeat) is worth ten points. An accurate scoreline earns 40 points.
Ray, who competes for his club side and the Premier League champions as well as England, is entering the fray at the eEuros finals after getting through the qualifying.
A group of eight will represent their nations at the finals in a straight knockout, playing for a $100,000 prize pool and a coveted spot in the world finals play-offs, with the Danish representative Anders Vejrgang defending the title he won last year.
"I am feeling really good for it," Ray remarked. "I've got a really good coach alongside me and practice has been going well.
"It's always an honour to play for your country. Of course when you are younger, you dream about doing it as an actual footballer, but when you go into this job and there is an opportunity to represent England, putting the shirt on is something special.
"I defeated Vejrgang 9-4 in qualifying to get here. I've played against him recently just in practice, and in other tournaments before - but I'd always lost to him in a tournament before.
"I believe he is the best player in the world so getting a win over him in a tournament like this just delivers a massive injection of confidence."
Premier League Weekend Preview
Saturday, 13 December
Chelsea vs Everton
Stamford Bridge, 15:00 GMT
The Blues were impressive against Arsenal at the end of November, when they secured a point after going down to 10 men, and many thought here we go, they could potentially be challengers for the crown.
Since then, however, they were overpowered by Leeds, looked lethargic against Bournemouth and this week got turned over by Atalanta in the Champions League.
So manager Enzo Maresca desperately requires a win here to restore momentum, but it will be a challenge because the Toffees are such a dangerous team.
Their key midfielders are playing really well and they have got a bit of momentum at the moment.
Current evidence suggests you would likely back the visitors, while the most sensible prediction would likely be a draw, but I am not going to be sensible.
Chelsea haven't given me any compelling evidence to back them recently, but I just have a gut instinct Chelsea will take this one because they are at home and they are due a win.
Sutton's prediction: 2-1
Stingray's prediction: With this being at the Bridge, I am going to back Chelsea. I think they will start off really well and go 2-0 up, then Everton will nick one back but then Chelsea score late. 3-1
AI's prediction: 2-0
Liverpool vs Brighton
Anfield, 15:00 GMT
I am at this game and it will be intriguing to see what we get from the Reds.
It was great to see for Reds boss Arne Slot to get such a crucial result at Inter Milan on Tuesday following all the stuff with Mohamed Salah this week.
Slot ought not to put up with that nonsense. I know Salah has been a great for Liverpool but fundamentally Slot just wants to win games and there is nothing personal in his team selection.
Liverpool changed their shape against Inter and went with a midfield diamond and two up top.
Everyone is going to be talking about whether Salah is selected for this game, but the only way he is going to be reintegrated is if he says sorry.
Slot's focus will be on winning this game, but it is a difficult fixture.
One might suggest it is the same for most teams but I find Brighton so unpredictable. I always feel they have got a goal in them, but they are vulnerable at the back too.
The Merseysiders need to get back to winning consistently, but I am not sure how much their efforts at the San Siro will have drained them.
I put a couple of Brighton players in my FPL team, so they will probably lose now - but I do fancy get something at Anfield.
Sutton's prediction: 2-2
Stingray's prediction: This is a game which is going to give Liverpool a bit more of their confidence back. Obviously they had a good win in midweek and they can build more momentum here. 2-1
AI's prediction: 3-1
Sunday, 14 December
Sunderland vs Newcastle
Stadium of Light, 14:00 GMT
Sunderland have had the benefit of a free week while Newcastle had to battle intensely against Bayer Leverkusen on Wednesday, only to let their lead slip away late on.
Apart from their brilliant performance against Everton a couple of weeks ago, Newcastle's away form hasn't been great, particularly straight after they've played in the Champions League.
It is anticipated that that trend to continue on Sunday, and their lack of freshness is likely to be a factor in how this game goes because of their rivals' high press.
Their match against Arsenal demonstrated how incessant Regis le Bris's side are. They overpowered the Gunners, and it was incredible to watch.
Commentators talks about how Granit Xhaka has been brilliant for the Black Cats, and he has been excellent, but Noah Sadiki, who plays in midfield with him, has also been one of the top transfers and deserves some attention too.
I am expecting this being the best game|most exciting fixture